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Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

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pneumonia in lung transplant patients :: Article Creator A Patient's Guide To Pneumonia: Causes, Treatment And Prevention Pneumonia — an infection of one or both of your lungs — can leave you coughing, feverish and feeling miserable.… Pneumonia — an infection of one or both of your lungs — can leave you coughing, feverish and feeling miserable. And sometimes, it can land you in the hospital struggling to breathe. While the rate of pneumococcal infections has been decreasing since the introduction of pneumococcal conjugate vaccines in 2000, more than 40% of the bacteria that cause pneumonia are resistant to one or more antibiotics, according to the Centers for Disease Control and Prevention. In October 2024, the CDC reported an increase in pneumoniae infections among children ages 2 to 17 in the United States. This rise in pneumonia cases is largely being caused by the bacteria Mycoplasma pneumoniae. M. Pneumoniae infections are generally m
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Dermatologic Manifestations of Pulmonary Disease



methotrexate lung :: Article Creator

Comparative Analysis Of ILD In Patients With RA And PsA On Biologics

Photo Credit: DouglasOlivares

The following is a summary of "Interstitial Lung Disease in Patients With Rheumatoid Arthritis or Psoriatic Arthritis Initiating Biologics and Controls: Data From 5 Nordic Registries," published in the September 2024 issue of Rheumatology by Provan et al. 

Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis (RA), but its prevalence in psoriatic arthritis (PsA) is unclear.  

Researchers conducted a retrospective study on patients with ILD in RA and PsA, investigating the debated role of methotrexate (MTX) in ILD development. 

They identified patients from 5 rheumatology registries, collecting data on demographics, MTX use, and disease activity. Matched general population subjects were sourced from 4 countries. The incidence of ILD during follow-up (up to 5 years) was assessed through national registries, excluding those with prior ILD. Adjusted hazard ratios (HRs) were calculated for ILD incidence between patients and the general population and for MTX users vs nonusers. 

The results showed that follow-up of 29,478 patients with RA and 10,919 patients with PsA initiating a first biologic disease-modifying antirheumatic drug (bDMARD), along with 362,087 population subjects, identified 225, 23, and 251 cases of ILD, respectively. The HRs for ILD compared to population subjects were 9.7 (95% CI 7.97-11.91) in RA and 4.4 (95% CI 2.83-6.97) in PsA. For patients with MTX comedication, HRs for ILD were 1.0 (95% CI 0.72-1.25) in RA and 0.9 (95% CI 0.38-2.05) in PsA. 

Investigators concluded that among patients with RA and PsA starting a bDMARD, the risk of ILD was higher than in the general population, particularly in RA. MTX comedication did not increase ILD risk. 

Source: jrheum.Org/content/early/2024/09/24/jrheum.2024-0252


Pemetrexed Disodium

In February 2004, pemetrexed disodium (Alimta; Eli Lilly), an anticancer drug that targets folate-dependent reactions that are essential for cell proliferation, became the first drug to be approved by the FDA for the treatment of the rare cancer malignant pleural mesothelioma. Its accelerated approval for the second-line treatment of non-small-cell lung cancer, which will considerably increase its market potential, followed in August 2004.





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