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fungus in lungs causes :: Article Creator Chinese Man Develops Fungal Infection In Lungs After Sniffing His Dirty Socks Every Day A man in China was diagnosed with a serious fungal lung infection reportedly caused by a rather unusual habit- regularly sniffing his dirty socks. The incident, which took place in Chongqing in southwestern China, was reported by Vice. According to the reports, the man had been dealing with a persistent cough and sought medical attention after over-the-counter medication failed to help. A medical scan revealed signs of a severe lung infection, prompting doctors to perform a bronchoscopy to collect samples from his respiratory tract. The tests confirmed he had aspergillosis, a lung disease caused by the Aspergillus fungus, which thrives in warm, damp environments. In an interview, the patient revealed he had a habit of smelling his socks after wearing them for extended periods. Doctors tested his socks and confirmed th...
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types of non small cell lung cancer :: Article Creator

Lung Cancer News

Dec. 17, 2024 — Researchers have used a chemical compound to light up treatment-resistant cancers on imaging scans, in a breakthrough that could help medical professionals better target and treat ...

Dec. 5, 2024 — Improvements in cancer prevention and screening have averted more deaths from five cancer types combined over the past 45 years than treatment advances, according to a modeling study. The study ...

Dec. 4, 2024 — A laboratory study provides evidence about how advanced age can be protective against cancer -- with implications for treating patients in different age ...

Nov. 12, 2024 — A research team has shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small ...

Nov. 11, 2024 — Extracellular vesicles (EVs) loaded with customizable anti-cancer antisense oligonucleotides suppressed cancer ...

Nov. 11, 2024 — Researchers have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface. Mutant RAS, they ...

Nov. 6, 2024 — Exhaled breath contains chemical clues to what's going on inside the body, including diseases like lung cancer. And devising ways to sense these compounds could help doctors provide early ...

Oct. 31, 2024 — A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which aging may promote lung cancer ...

Oct. 31, 2024 — Researchers have shown that the IGFBP3 protein plays a relevant role in human lung development. The results of the study, which used organoids derived from embryonic lungs, open up new perspectives ...

Oct. 9, 2024 — Researchers have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more ...

Oct. 7, 2024 — Researchers have discovered a natural immune mechanism in mice that stops escaped cancer cells from developing into tumors elsewhere in the ...

Oct. 4, 2024 — The University of Cincinnati's Debanjan Bhattacharya is first author of new research published in Cancers that found the drug AM-101 improves the effectiveness and survival rate of radiation ...

Sep. 25, 2024 — Researchers have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive ...

Sep. 13, 2024 — Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers. The investigational mRNA cancer immunotherapy is ...

Sep. 12, 2024 — Researchers examined the impact of obesity in relation to treatment and mortality from data on over 500,000 lung cancer patients. This study suggests that immunotherapy may not be the optimal ...

Sep. 11, 2024 — A team of doctors and researchers have identified a new, rare type of small cell lung cancer that primarily affects younger people who have never ...

Aug. 23, 2024 — A team of researchers has created a digital pathology platform based on artificial intelligence. The platform uses new algorithms developed by the team and enables fully automated analysis of tissue ...

July 17, 2024 — A medication used to treat diabetic neuropathy may make chemotherapy treatments more effective for patients with lung cancer, according to new ...

July 11, 2024 — A new study finds four in 10 cancer cases and about one-half of all cancer deaths in adults 30 years old and older in the United States (or 713,340 cancer cases and 262,120 cancer deaths in 2019) ...

June 14, 2024 — Researchers have developed a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells and enhances the immune system's ability to fight cancer. The team showed promising ...


Breakthroughs In Battle Against Common Lung Cancer

Eighty-five percent of diagnosed cases of lung cancer are non-small cell lung cancer (NSCLC). In this group, 5% of patients show molecular alterations in the ALK gene involved in cell multiplication. The use of inhibitors against this oncogene - one of the most effective strategies against this type of cancer - has benefited many patients. But, is it possible to know if the treatment will be effective in all those affected?

Now, a study led by the University of Barcelona reveals that the functional assay dynamic BH3 profiling (DBP) can predict whether this treatment will be effective in these cancer patients and thus improve personalized therapies. This technique achieves with tumours something very similar to what an antibiogram achieves with a bacterial infection: determining which therapy will be most effective by testing it directly on living cells.

​​​​​​​

The technique, which helps to select the best drug for each patient, was patented in 2015 by the Dana-Farber Cancer Institute (Boston, United States) and its co-inventor is Joan Montero, professor at the UB's Faculty of Medicine and Health Sciences and at the Bioengineering, Biomaterials and Nanomedicine Networking Biomedical Research Centre (CIBER-BBN).

The new study, published in Nature's journal Cell Death and Disease , is led by Professor Joan Montero and its first author is researcher Fernando Martín, a member of the UB, the Institute for Bioengineering of Catalonia (IBEC) and CIBERBBN. Teams from the UB's Faculty of Physics, Hospital Clínic, August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and the Catalan Institute of Oncology (ICO) are also collaborating in the paper.

The study, conducted using animal models and patient biopsies, also reveals for the first time that the MCL-1 protein plays a key role in tumour resistance to this type of therapy. It also shows that molecules known as BH3 mimetics can improve the effect of cancer treatments by preventing tumour adaptations to inhibitors of anaplastic lymphoma protein kinase (ALK), one of the main treatments for this cancer.

Predicting the response of the most common lung cancer drugs

Each tumour is unique, and predicting the therapeutic response to non-small cell lung cancer is a breakthrough in personalized medicine. Given this challenge in biomedicine, the study confirms that the dynamic BH3 profiling technique has an excellent predictive capacity for tumour cell response to ALK inhibitors.

ALK inhibitors are used early in disease in patients with non-small cell lung cancer who show molecular alterations in this oncogene. Currently, four generations of ALK inhibitors have been developed with clinical efficacy superior to chemotherapy.

/Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

Lab-grown Lung Cancer Cells Show Potential To Revolutionise Treatment

Cancer Research scientists have developed a new cell-based model of lung squamous cell carcinoma (LUSC), a type of lung cancer, which has the potential to develop more effective treatments for the disease as well as other cancers.

Conducted at the Cancer Research Manchester Institute, the study turned healthy donor lung cells into cancerous cells. The process was replicated across all three donors using techniques including CRISPR gene editing. The discovery could lead to more targeted treatments for the disease, and other cancers if the modelling technique is applied effectively.

Despite LUSC being one of the main types of non-small cell lung cancer, the most common form of lung cancer, understanding and treatment options remain limited. According to NHS data, only one in five lung cancer patients in England survive the disease for five years or more.

"Patients have poor survival outcomes, and those treated successfully can face long-term side effects," said Cancer Research UK's Executive Director of Research and Innovation, Iain Foulkes.

Additionally, the LUSC model has the potential to improve early detection of the disease. It replicates early stages of the cancer, allowing clinicians to spot initial signs and development in patients.

The cell-based modelling technique may also improve the efficiency and scale of other modelling experiments by replacing animal testing with laboratory models. Trials on animals are not always reproducible in humans, inhibiting further experimentation.

Foulkes commented on the significant potential of the modelling technique: "Research like this opens the door to better visualise the efficacy of drug treatments on cancer cells."

Cancer Research UK Manchester Institute Fellow, Carlos Lopez-Garcia, said: "With this new strategy to model LUSC, we are in a much better position to understand how this disease progresses. Developments like these accelerate research on new therapies and improve existing ones, powering us through clinical advancements for years to come."





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