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A Lack Of Drugs For Antibiotic-resistant Gram-negative Bacteria
Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nature Rev. Drug Discov. 6, 29–40 (2007).
Article CAS Google Scholar
Bradley, J. S. Et al. Anti-infective research and development-problems, challenges, and solutions. Lancet Infect. Dis. 7, 68–78 (2007).
Article Google Scholar
Talbot, G. H. Et al. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin. Infect. Dis. 42, 657–668 (2006).
Article Google Scholar
Paterson, D. L. & Bonomo, R. A. Extended-spectrum β-lactamases: a clinical update. Clin. Microbiol. Rev. 18, 657–686 (2005).
Article CAS Google Scholar
Mammeri, H. Et al. AmpC β-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins. Antimicrob. Agents Chemother. 48, 4050–4053 (2004).
Article CAS Google Scholar
Mammeri, H., Poirel, L., Bemer, P., Drugeon, H. & Nordmann, P. Resistance to cefepime and cefpirome due to a 4-amino-acid deletion in the chromosome-encoded AmpC β-lactamase of a Serratia marcescens clinical isolate. Antimicrob. Agents Chemother. 48, 716–720 (2004).
Article CAS Google Scholar
Kim, J. Y. Et al. Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C β-lactamase. Mol. Microbiol. 60, 907–916 (2006).
Article CAS Google Scholar
Wachino, J. Et al. Horizontal transfer of blaCMY-bearing plasmids among clinical Escherichia coli and Klebsiella pneumoniae isolates and emergence of cefepime-hydrolyzing CMY-19. Antimicrob. Agents Chemother. 50, 534–541 (2006).
Article CAS Google Scholar
Poirel, L. Et al. Emergence in Klebsiella pneumoniae of a chromosome-encoded SHV β-lactamase that compromises the efficacy of imipenem. Antimicrob. Agents Chemother. 47, 755–758 (2003).
Article CAS Google Scholar
Lee, S. H., Jeong, S. H. & Cha, S. S. Screening for carbapenems-resistant Gram-negative bacteria. Lancet Infect. Dis. 6, 682–684 (2006).
Article Google Scholar
Lobkovsky, E. Et al. Evolution of an enzyme activity: crystallographic structure at 2 Å resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase. Proc. Natl Acad. Sci. USA 90, 11257–11261 (1993).
Article CAS Google Scholar
Crichlow, G. V. Et al. Structure of the extended-spectrum class C β-lactamase of Enterobacter cloacae GC1, a natural mutant with a tandem tripeptide insertion. Biochemistry 38, 10256–10261 (1999).
Article CAS Google Scholar
Anderson, A. C. The process of structure-based drug design. Chem. Biol. 10, 787–797 (2003).
Article CAS Google Scholar
Powers, R. A., Morandi, F. & Shoichet, B. K. Structure-based discovery of a novel, noncovalent inhibitor of AmpC β-lactamase. Structure 10, 1013–1023 (2002).
Article CAS Google Scholar
Fox, J. L. The business of developing antibacterials. Nature Biotech. 24, 1521–1528 (2006).
Article CAS Google Scholar
Is Pneumonia Contagious? Yes, When It's Caused By Bacteria Or Viruses
Pneumonia is an infection that causes the air sacs in one or both lungs to fill with fluid or pus. Each year, more than 250,000 Americans are hospitalized with pneumonia, and about 50,000 die from the disease.
Signs and symptoms of pneumonia can vary depending on the type and severity, but they typically include:
There are many different types of pneumonia — and most of them can be contagious. Here's what you need to know about the types of pneumonia, how they spread, and how to protect yourself.
Which types of pneumonia are contagious?Pneumonia is contagious when it is caused by infectious pathogens, like bacteria or viruses. This is the case with most types of pneumonia, including:
If you have bacterial pneumonia, you'll remain contagious until you've been on antibiotics for 24 to 48 hours. If you have viral pneumonia, you will be contagious until your symptoms subside.
However, pneumonia is not contagious when it is caused by a foreign substance, like when food, drink, or saliva enters the lungs and causes inflammation. This is called aspiration pneumonia, which accounts for about 5% to 15% of pneumonia cases acquired outside of health care facilities.
Risk factors for aspiration pneumonia include anything that may make swallowing more difficult, such as:
The way pneumonia develops and spreads depends on the type and cause, says David Cutler, MD, family medicine physician at Providence Saint John's Health Center.
Many types of microbes — including bacteria, viruses, and fungi — can cause pneumonia. These germs commonly spread when an infected person coughs or sneezes and expels bacterial or viral droplets. These droplets could land on a surface, such as a table or a doorknob, infecting others who come into contact with the surface and then touch their eyes or mouth. Or, you may breathe in respiratory droplets from an infected person.
Most of the time, your immune system can effectively fight off these germs. But sometimes they overpower your body's natural defenses and invade your lungs. In response, your body produces white blood cells to fight off the attackers, filling the lung's air sacs with pus or cellular debris and causing pneumonia.
Adults older than 65 and children under the age of two are at an increased risk of developing pneumonia. This is because an older adult's immune system isn't as robust as a young adult's, and a young child's immune system is still developing.
Those who are immunocompromised or take medication that suppresses the immune system, like oral corticosteroids, are also at an increased risk of pneumonia because their bodies may not be able to fight off the germs that cause the infection.
How to prevent the spread of pneumoniaTo reduce your risk of getting or spreading pneumonia, you should do the following:
In addition, there are several vaccines that can help protect against some viruses and bacteria that cause pneumonia, Cutler says.
These include the following:
Most people who have pneumonia are effectively treated at home, according to the NHLBI. But pneumonia can also be a life-threatening condition, especially for older adults or people with chronic lung problems, like asthma.
Overall, getting vaccinated, practicing good hygiene, and staying away from someone you know is sick can reduce your risk for developing pneumonia, Cutler says.
If you do experience signs of pneumonia, like difficulty breathing, chest pain, and a persistent fever of 102 degrees Fahrenheit or higher, you should seek immediate medical attention.
Related articles from Health Reference:Is Pneumonia Contagious? Yes, When It's Caused By Bacteria Or Viruses
Pneumonia is an infection that causes the air sacs in one or both lungs to fill with fluid or pus. Each year, more than 250,000 Americans are hospitalized with pneumonia, and about 50,000 die from the disease.
Signs and symptoms of pneumonia can vary depending on the type and severity, but they typically include:
There are many different types of pneumonia — and most of them can be contagious. Here's what you need to know about the types of pneumonia, how they spread, and how to protect yourself.
Which types of pneumonia are contagious?Pneumonia is contagious when it is caused by infectious pathogens, like bacteria or viruses. This is the case with most types of pneumonia, including:
If you have bacterial pneumonia, you'll remain contagious until you've been on antibiotics for 24 to 48 hours. If you have viral pneumonia, you will be contagious until your symptoms subside.
However, pneumonia is not contagious when it is caused by a foreign substance, like when food, drink, or saliva enters the lungs and causes inflammation. This is called aspiration pneumonia, which accounts for about 5% to 15% of pneumonia cases acquired outside of health care facilities.
Risk factors for aspiration pneumonia include anything that may make swallowing more difficult, such as:
The way pneumonia develops and spreads depends on the type and cause, says David Cutler, MD, family medicine physician at Providence Saint John's Health Center.
Many types of microbes — including bacteria, viruses, and fungi — can cause pneumonia. These germs commonly spread when an infected person coughs or sneezes and expels bacterial or viral droplets. These droplets could land on a surface, such as a table or a doorknob, infecting others who come into contact with the surface and then touch their eyes or mouth. Or, you may breathe in respiratory droplets from an infected person.
Most of the time, your immune system can effectively fight off these germs. But sometimes they overpower your body's natural defenses and invade your lungs. In response, your body produces white blood cells to fight off the attackers, filling the lung's air sacs with pus or cellular debris and causing pneumonia.
Adults older than 65 and children under the age of two are at an increased risk of developing pneumonia. This is because an older adult's immune system isn't as robust as a young adult's, and a young child's immune system is still developing.
Those who are immunocompromised or take medication that suppresses the immune system, like oral corticosteroids, are also at an increased risk of pneumonia because their bodies may not be able to fight off the germs that cause the infection.
How to prevent the spread of pneumoniaTo reduce your risk of getting or spreading pneumonia, you should do the following:
In addition, there are several vaccines that can help protect against some viruses and bacteria that cause pneumonia, Cutler says.
These include the following:
Most people who have pneumonia are effectively treated at home, according to the NHLBI. But pneumonia can also be a life-threatening condition, especially for older adults or people with chronic lung problems, like asthma.
Overall, getting vaccinated, practicing good hygiene, and staying away from someone you know is sick can reduce your risk for developing pneumonia, Cutler says.
If you do experience signs of pneumonia, like difficulty breathing, chest pain, and a persistent fever of 102 degrees Fahrenheit or higher, you should seek immediate medical attention.
Related articles from Health Reference:
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