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Long-lasting Immunotherapy Response In Stage IV Lung Cancer With Brain Metastasis
image:
Figure 1. Brain MRI at diagnosis and last Brain MRI performed. The image shows a temporal metastatic lesion at diagnosis (A) and last Brain MRI with maintained complete response (B), in postcontrast 3D T1-weighted.
view moreCredit: 2024 Costa and Magalhães
"In the last decade, immunotherapy agents changed the treatment landscape for Non-Small Cell Lung Cancer (NSCLC)."
BUFFALO, NY - October 18, 2024 – A new case report was published in Oncoscience (Volume 11) on October 8, 2024, entitled, "Complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer with brain metastasis."
As highlighted in the abstract of this report, approximately 20% of lung cancer patients have brain metastases at diagnosis, which is associated with a worse prognosis and negatively impacts quality of life. The emergence of new systemic treatment options, such as immune checkpoint inhibitors (ICI) and targeted therapies, has changed the prognosis for stage IV lung cancer patients. However, the impact of treatment sequencing—both local and systemic—in patients with stage IV lung cancer and brain metastases remains unclear.
Researchers Mafalda Costa and Helena Magalhães from the Department of Medical Oncology, Hospital Pedro Hispano in Matosinhos, Portugal present the case of a 51-year-old man diagnosed with stage IV non-small cell lung cancer (NSCLC) and brain metastasis. After undergoing whole brain radiotherapy (WBRT), the patient achieved both intracranial and extracranial complete response following second-line treatment with an immune checkpoint inhibitor. Currently, he has an overall survival of 87 months and a progression-free survival of 73 months, maintaining an optimal quality of life.
"We hypothesized that treatment sequencing of WBRT and immunotherapy could explain this unexpected outcome."
Continue reading: DOI: https://doi.Org/10.18632/oncoscience.609
Corresponding author: Mafalda Costa - mafalda.Teixeiracosta@ulsm.Min-saude.Pt
Keywords: cancer, lung cancer, complete response, immune checkpoint inhibitors, brain metastasis, whole-brain radiotherapy
About Oncoscience:
Oncoscience is a peer-reviewed, open-access, traditional journal covering the rapidly growing field of cancer research, especially emergent topics not currently covered by other journals. This journal has a special mission: Freeing oncology from publication cost. It is free for the readers and the authors.
Oncoscience is indexed and archived by PubMed, PubMed Central, Scopus, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
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Method of ResearchCase study
Subject of ResearchNot applicable
Article TitleComplete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer with brain metastasis
Article Publication Date8-Oct-2024
COI StatementAuthors have no conflicts of interest to declare.
Disclaimer: AAAS and EurekAlert! Are not responsible for the accuracy of news releases posted to EurekAlert! By contributing institutions or for the use of any information through the EurekAlert system.
Battling Stage 4 Cancer, Country Singer Shares Shocking News On Social Media About Recent Biopsy
Country singer Joshua Ray Walker, who is fighting for his life against cancer, made a shocking announcement on social media recently: After being told that he likely had Stage IV lung cancer, a recent lung biopsy surgery revealed that the organ is cancer free.
The country star's Instagram post was captioned: "I've been anxious to update you, but I wanted to wait until I was off pain meds and all the most recent scans, tests and lab results come back. I'm so excited to share with you that my pre-surgery diagnosis was incorrect, I've beat the odds and to everyone's complete surprise, my lungs are cancer free!"
Walker recently underwent surgery on his lungs, enduring five holes drilled through his rib cage and the removal of portions of his lung as part of a biopsy.
For now, Walker happily announced his medical team indicated there was "no discernible amount of cancer anywhere in my body at the moment!"
The post went on to say: "The recovery from this surgery has really kicked my butt. All of the medical news, good and bad, has been an emotional rollercoaster. Thank y'all so, so much for your kindness and all of your donations.
"This has been a life-altering couple of months, but for the first time all year, it's for the better! Your generosity is going to allow me to continue focusing on my health while I monitor my body for cancer and begin building my strength so that I can tour again."
Walker said he must undergo frequent tests and scans across the next five years.
ROAD TO HEALING
Walker remains focused on starting his road to being "the healthiest version" of himself, thankful for the support he has received to overcome his "insurmountable financial situation."
"Your donations have and will continue to help me pay my personal and medical debt," Walker has said. "They will supplement lost wages and out-of-pocket expenses I've accrued since my diagnosis, as well as future expenses as I continue to heal.
"I'm so excited to be alive, I'm excited to share this incredible news with you, and I'm excited to make the most of this opportunity. I love y'all so much; thank you for loving me back."
Fans were delighted with his news that there was no detectable cancer in the latest series of tests, with comments like, "Yesss, amen, the best news ever. God bless ❤️🇨🇦🙏🏻🙏🏻❤️" and "Great news!!!! Looking forward to seeing you on stage again!!!!"
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Complete Response To Immunotherapy In Stage IV Lung Cancer
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SummaryA case report highlights a 51-year-old man with stage IV non-small cell lung cancer and brain metastasis who received whole brain radiotherapy followed by immune checkpoint inhibitor treatment. The patient achieved complete response, with overall survival at 87 months and progression-free survival at 73 months, maintaining quality of life.
Key TakeawaysA new case report was published in Oncoscience (Volume 11) on October 8, 2024, entitled, "Complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer with brain metastasis."
As highlighted in the abstract of this report, approximately 20% of lung cancer patients have brain metastases at diagnosis, which is associated with a worse prognosis and negatively impacts quality of life. The emergence of new systemic treatment options, such as immune checkpoint inhibitors (ICI) and targeted therapies, has changed the prognosis for stage IV lung cancer patients. However, the impact of treatment sequencing—both local and systemic—in patients with stage IV lung cancer and brain metastases remains unclear.
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Subscribe for FREEResearchers Mafalda Costa and Helena Magalhães from the Department of Medical Oncology, Hospital Pedro Hispano in Matosinhos, Portugal present the case of a 51-year-old man diagnosed with stage IV non-small cell lung cancer (NSCLC) and brain metastasis. After undergoing whole brain radiotherapy (WBRT), the patient achieved both intracranial and extracranial complete response following second-line treatment with an immune checkpoint inhibitor. Currently, he has an overall survival of 87 months and a progression-free survival of 73 months, maintaining an optimal quality of life.
"We hypothesized that treatment sequencing of WBRT and immunotherapy could explain this unexpected outcome."
Reference: Costa M, Magalhães H. Complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer with brain metastasis. Oncoscience. 2024;11:92-98. Doi: 10.18632/oncoscience.609
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