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Analysis Spotlights Sperm Defects In Month After COVID Infection, But Not At 90 Days

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In the 30 days after COVID-19 infection, total sperm count, sperm concentration, total sperm motility (movement), and progressive motility were significantly reduced in a cohort of Chinese men, with the most severe effects in those with moderate to high fever, researchers from Sichuan Provincial Maternity and Child Health Care Hospital report in Scientific Reports. 

The researchers tracked semen quality in 58 men for up to 109 days after COVID-19 diagnosis and used a linear mixed-effects model to analyze semen parameters at different time points before and after infection. They noted that previous studies suggest that angiotensin-converting enzyme 2 (ACE2) facilitates SARS-CoV-2 entry into testicular cells, where it leads to testes injury and impairs sperm production.

Higher fever, worse impact

While there was no significant difference in semen volume before or after COVID-19 diagnosis, median total sperm count and concentration were lower after infection. Total sperm motility and progressive motility were significantly lower after diagnosis, and the percentage of non-moving sperm was higher. 

Rates of sperm survival and normal sperm form decreased, with greater head defects but similar numbers of sperm with neck, mid-piece, or tail defects. No differences were noted in the number of round cells, anti-sperm antibodies, semen liquefaction time, or viscosity before or after COVID-19 infection.

Fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible.

The greatest drop in sperm count and concentration occurred within 30 days, followed by a gradual recovery and normalization by 90 days. The percentage of normal sperm fell, and the percentage of sperm with head defects significantly increased from 30 to 60 days, followed by recovery. An initial drop in sperm survival returned to baseline by 30 days.

Patients with a moderate or high fever saw a statistically significant decline in semen parameters, while those with a mild fever did not.

"Fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible," the study authors concluded.

Household Study Shows Dogs, Cats Share Multidrug-resistant Bacteria With Their Owners

iLexx / iStock

In the 30 days after COVID-19 infection, total sperm count, sperm concentration, total sperm motility (movement), and progressive motility were significantly reduced in a cohort of Chinese men, with the most severe effects in those with moderate to high fever, researchers from Sichuan Provincial Maternity and Child Health Care Hospital report in Scientific Reports. 

The researchers tracked semen quality in 58 men for up to 109 days after COVID-19 diagnosis and used a linear mixed-effects model to analyze semen parameters at different time points before and after infection. They noted that previous studies suggest that angiotensin-converting enzyme 2 (ACE2) facilitates SARS-CoV-2 entry into testicular cells, where it leads to testes injury and impairs sperm production.

Higher fever, worse impact

While there was no significant difference in semen volume before or after COVID-19 diagnosis, median total sperm count and concentration were lower after infection. Total sperm motility and progressive motility were significantly lower after diagnosis, and the percentage of non-moving sperm was higher. 

Rates of sperm survival and normal sperm form decreased, with greater head defects but similar numbers of sperm with neck, mid-piece, or tail defects. No differences were noted in the number of round cells, anti-sperm antibodies, semen liquefaction time, or viscosity before or after COVID-19 infection.

Fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible.

The greatest drop in sperm count and concentration occurred within 30 days, followed by a gradual recovery and normalization by 90 days. The percentage of normal sperm fell, and the percentage of sperm with head defects significantly increased from 30 to 60 days, followed by recovery. An initial drop in sperm survival returned to baseline by 30 days.

Patients with a moderate or high fever saw a statistically significant decline in semen parameters, while those with a mild fever did not.

"Fever severity during SARS-CoV-2 infection may constitute the main influencing factor in reducing semen parameters in patients after recovery, but the effect is reversible," the study authors concluded.

Man Beats Cancer 4 Times, Regains Speech After 5 Yrs & Starts Law Prog

Noida: A 53-year-old man from Vaishali regained his speech after five years when he beat oral cancer for the fourth time. Doctors at a private hospital in Ghaziabad, where he underwent the latest surgery, said cancer was found in different parts of the oral cavity each time.In 2018, Sanjeev Kumar underwent a successful surgery for right buccal mucosa carcinoma for the first time. "I had a white patch on the insides of the cheeks, which we initially thought was an ulcer. When it did not go away for more than a few weeks, I consulted a doctor at a private hospital in Vaishali and it was diagnosed as oral cancer," said Kumar.Despite a brief period of remission, he again faced two concurrent cancers near the lower jaw and right floor of the mouth in Jan 2022. The next year, the marketing professional was operated on for another cancer inside his cavity."It wasn't an easy journey. I lost a part of my tongue in the latest surgery. However, I have regained my speech ability over time along with other oral activities," he said. Sanjeev has also enrolled in a law course to keep himself busy.Dr Sowrabh Kumar Arora, senior director of surgical oncology at Max Vaishali, said, "The four surgeries were conducted by a team of doctors after several examinations. Along with surgery and medication, the willpower of a patient and his family members is crucial for recovery. Kumar's proactive approach to regular follow-up visits played a pivotal role in early detection and timely intervention, enabling successful management of his condition. Despite facing four distinct occurrences of cancer within the oral cavity, Kumar's perseverance, coupled with meticulous post-operative care and rehabilitation, has contributed to his remarkable recovery and overall well-being."Arora and Dr Pawan Gupta, also a senior director of surgical oncology at Max, led the team of doctors who operated on Sanjeev."People usually don't pay attention to oral ulcers or the possibilities of them turning into cancer. If any oral problem, including lack of taste, mouth ulcers, change of voice or difficulty in eating, is observed, one must immediately consult a doctor. Cancer detected at an early stage can be curable," Gupta said.He said consumption of tobacco was one of the main causes of oral cancer.

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