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stage 3 small cell lung cancer life expectancy :: Article Creator Small-Cell Lung Cancer: Symptoms, Causes, Tests, Treatment, And More - WebMD When cells of the lung start growing rapidly in an uncontrolled way, the condition is called lung cancer This disease can affect any part of the lung, and it's the leading cause of cancer deaths in both women and men in the United States, Canada, and China. There are two main types of lung cancer. Small-cell lung cancer (SCLC), sometimes called small-cell carcinoma, causes about 10%-15% of all lung cancer. Non-small-cell lung cancer (NSCLC) causes the rest. There are two main types: Small-cell carcinoma (oat cell cancer) Combined small-cell carcinoma Both include many types of cells that grow and spread in different ways. They're named according to what the cells look like under a microscope. Small-cell lung cancer differs from non-small-cell lung cancer in some key ways. Small-cell lung...
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Considering taking a vitamin or supplement to treat Bronchopulmonary+Dysplasia? Below is a list of common natural remedies used to treat or reduce the symptoms of Bronchopulmonary+Dysplasia. Follow the links to read common uses, side effects, dosage details and read user reviews for the drugs listed below.

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Early Ibuprofen Not Beneficial For Preemies With Patent Ductus Arteriosus

For extremely preterm infants, the risk for death or moderate or severe bronchopulmonary dysplasia is not significantly lower among those receiving early treatment for patent ductus arteriosus (PDA) with ibuprofen versus placebo, according to a study published in the Jan. 25 issue of the New England Journal of Medicine.

Samir Gupta, M.D., from Sidra Medicine in Doha, Qatar, and colleagues conducted a multicenter, randomized, double-blind, placebo-controlled trial assessing early ibuprofen treatment (≤72 hours after birth) for a large PDA (diameter ≥1.5 mm with pulsatile flow) in extremely preterm infants. Overall, 326 and 327 infants were assigned to receive ibuprofen and placebo, respectively; 324 and 322 had data available for outcome analyses. A composite of death or moderate or severe bronchopulmonary dysplasia evaluated at 36 weeks of postmenstrual age was the primary outcome.

The researchers found that a primary outcome event occurred in 69.2 and 63.5% of infants in the ibuprofen and placebo groups, respectively (adjusted risk ratio, 1.09; 95% confidence interval [CI], 0.98 to 1.20; P = 0.10); 13.6 and 10.3% of infants, respectively, died (adjusted risk ratio, 1.32; 95% confidence interval, 0.92 to 1.90). Moderate or severe bronchopulmonary dysplasia occurred in 64.2 and 59.3% of the ibuprofen and placebo groups, respectively, among the infants who survived to 36 weeks of postmenstrual age (adjusted risk ratio, 1.09; 95%t confidence interval, 0.96 to 1.23).

"Our results are broadly consistent with those of other studies of early targeted treatment of PDA with ibuprofen that have not shown a convincing benefit with respect to clinical outcomes," the authors write.

More information: Samir Gupta et al, Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen, New England Journal of Medicine (2024). DOI: 10.1056/NEJMoa2305582

Jill L. Maron, Patent Ductus Arteriosus—To Close or Not to Close?, New England Journal of Medicine (2024). DOI: 10.1056/NEJMe2313738

2024 HealthDay. All rights reserved.

Citation: Early ibuprofen not beneficial for preemies with patent ductus arteriosus (2024, January 25) retrieved 4 February 2024 from https://medicalxpress.Com/news/2024-01-early-ibuprofen-beneficial-preemies-patent.Html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.





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