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Sep. 12, 2023 — An international team of researchers has demonstrated that a combination of inhibitors may suppress tumor growth and prevent relapse in patients with certain cancers, including head and neck squamous ...
Sep. 7, 2023 — Women exposed to air pollution give birth to smaller babies, according to new research. The research also shows that women living in greener areas give birth to bigger babies and this may help ...
Sep. 7, 2023 — Researchers reveal for the first time that high blood sugar levels in type 2 diabetes can play a causal role in lung ...
Sep. 5, 2023 — A new study has shown that a subtype of avian flu virus, endemic in poultry farms in China, is undergoing mutational changes, which could increase the risk of the disease being passed on to ...
Aug. 30, 2023 — Fresh discoveries about a type of immune cells could give lung cancer patients a more accurate prognosis and better identify who will benefit from immunotherapies. Researchers found that the location ...
Aug. 25, 2023 — High levels of some minerals and metals in environmental water supplies may increase the risk of nontuberculous mycobacteria (NTM) pulmonary infections in people with cystic fibrosis, according to a ...
Aug. 24, 2023 — Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary ...
Aug. 16, 2023 — Researchers have found that molecules in vegetables like broccoli or cauliflower help to maintain a healthy barrier in the lung and ease ...
Aug. 11, 2023 — Yoga and breathing control practices, in combination with aerobic training, are particularly key exercises for asthmatic people seeking to improve their lung function, a new peer-reviewed study ...
Aug. 9, 2023 — New findings may lead to relapse-free treatment for a sizeable subgroup of lung cancer patients. In a study in mice, scientists have identified a biomarker that may help physicians select lung cancer ...
Aug. 8, 2023 — Overly active immune cells are often behind lung damage in diseases such as Covid-19. Researchers have developed an RNA agent for a lung spray that slows the activity of these cells, known as ...
July 25, 2023 — Having a food allergy as a baby is linked to asthma and reduced lung function later in childhood, according to a new ...
July 20, 2023 — Omega-3 fatty acids, which are abundant in fish and fish oil supplements, appear promising for maintaining lung health, according to new evidence from a large, multi-faceted study in healthy adults. ...
July 7, 2023 — The mucus in the airways is not as sticky, inflammation in the lungs significantly reduced: Triple combination therapy can achieve these positive, lasting effects in patients with cystic fibrosis ...
June 22, 2023 — Small-cell lung cancer is a particularly aggressive type of tumor with a consistently high mortality rate. In recent years, the research of scientists has significantly contributed to a better ...
June 8, 2023 — The largest and most comprehensive cell map of the human lung has been completed. The Human Lung Cell Atlas reveals the great diversity of cell types in the lung and shows key differences between ...
June 1, 2023 — Researchers have collaborated to refine a cell culture technology platform that grows genetically identical lung buds from human embryonic stem ...
May 24, 2023 — A new study has shown that human T cells have an important role to play in controlling ...
Apr. 21, 2023 — Storing donor lungs for transplant at 10 degrees Celsius markedly increases the length of time the organ can live outside the body according to new ...
Mar. 31, 2023 — A new type of nanoparticle can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins. Researchers hope to use them to develop new treatments for cystic fibrosis ...
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Tarlatamab Showed Shows Promise In Small-Cell Lung Cancer
In a recent study, tarlatamab resulted in improved objective responses and improved survival outcomes in patients with small-cell lung cancer.
Tarlatamab showed promise in treating small-cell lung cancer.
Tarlatamab, an immunotherapy drug, was shown to improve objective response rate (percentage of patients whose disease shrunk or disappeared) and overall survival (time from treatment until death of any cause) outcomes when given to patients with small-cell lung cancer in a 10-mg dose every two weeks, according to findings published in the New England Journal of Medicine.
Previously, a phase 1 trial tested outcomes of tarlatamab in patients with previously treated small-cell lung cancer. The drug showed successful activity, targeting delta-like ligand 3 and CD3, and had promising antitumor activity in this population.
The phase 2 DeLLphi-301 study, compiled of 222 patients, evaluated the antitumor activity within given patient population. The study also focused on the efficiency, safety side-effect profile and pharmacokinetics of the drug in patients with small-cell lung cancer.
The study was broken up into three parts: Part one was a dose comparison within 180 patients in the study, where patients received either 10 mg of tarlatamab or 100 mg within a 60-minute infusion. Part two focused on the patient population that been enrolled in the selected dose. Part three focused on the efficiency and safety of the overall drug within the patient population.
Patients within the study had to be at least 18, with a confirmed diagnosis of relapsed/ refractory small-cell lung cancer with at least one line of therapy.
The primary endpoint of the study was to identify the overall objective response (representing the efficiency of the drug to the disease). Secondary endpoints of the study were: duration of objective response, disease control, progression-free survival (the time from randomization/initiation of treatment to the occurrence of disease progression or death), overall survival, side effects and within the treatment serum concentration of the drug and antibody within the drug.
A total of 176 patients were randomly assigned to receive a 10 mg dose of tarlatamab (88 patients) or 100 mg (88 patients). The 10 mg dose showed better outcomes, and was the dose used into part two and three. The median duration of treatment for tarlatamab was 5.1 months in the 10 mg group and 3.7 months in the 100 mg dose. The median follow up was 10.6 months in the 10 mg dose and 10.3 months in the 100 mg dose.
Sixty-eight patients responded to therapy, with a duration of six months in 40 patients and nine months in 20 patients. Median progression-free survival was 4.9 months in the 10 mg dose and 3.9 months in the 100 mg dose. Six- and nine-month overall survival rates were 40% and 28% within the 10 mg dose groups and 73% and 68% in the 100 mg dose group.
Within the study, the 10 mg dose of tatlatamab given every two weeks resulted in a successful objective response and improved survival outcomes in patients with small-cell lung cancer.
Treatment-related side effects within the study included: cytokine-release syndrome (51% in 10 mg dose and 61% in 100 mg dose), decreased appetite (29% in the 10mg dose and 44% in the 100mg dose), pyrexia (35% in the 10mg dose and 33% in the 100mg dose) and anemia (26% in the 10mg dose and 25% in the 100mg dose).
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Lung Cancer: Causes, Symptoms, Treatment For The Disease
Lung cancer is the leading cause of cancer deaths in the United States.
>> Read more trending news
The Centers for Disease Control and Prevention says lung cancer is one of the most common cancers in the United States. It is also one of the leading causes of cancer deaths globally, according to Mayo Clinic. The second most common form of cancer is skin cancer. Breast cancer for women and prostate cancer for men after that.
There are two types of lung cancer - small cell lung cancer and non-small cell lung cancer. Non-small cell lung cancer is more common.
Lung cancer is a disease where malignant cancer cells form in lung tissue, according to the National Cancer Institute.
"Big Bang Theory" star Kate Micucci revealed she underwent surgery recently for lung cancer on TikTok, according to CNN. Micucci said her diagnosis was not something she had expected.
"Hey everybody, this is not a TikTok, it's a 'Sick Tok,'" she said. "I'm in the hospital but it's because I had lung cancer surgery yesterday. They caught it really early."
"It's really weird, because I've never smoked a cigarette in my life. So, you know, it was a surprise. But also I guess, it happens and the greatest news is they caught it early, they got it out, I'm all good," Micucci said, according to CNN.
"Brooklyn Nine-Nine" actor Andrew Braugher died at the age of 61 on Dec. 11, according to Variety. The cause at the time was a "brief illness."
Braugher's publicist said his cause of death was lung cancer, according to the New York Times. He was diagnosed a few months ago.
According to the National Library of Medicine, other famous names who died from the disease include Walt Disney, Lucille Ball, Desi Arnez Humphrey Bogart and many others.
Causes of lung cancer, according to the CDC:The number one cause of lung cancer is cigarette smoking, the CDC said. It can also come from tobacco, breathing secondhand smoke, substance exposure like asbestos, certain gene mutations or family history.
"Lung cancer can happen in people who never smoked or smoked fewer than 100 cigarettes in their lifetime," the CDC said.
Symptoms, according to the CDC:Popular Posts
Preventing, controlling spread of animal diseases focus of forum at Penn State - Pennsylvania State University
UNIVERSITY PARK, Pa. — An outbreak of the highly pathogenic avian influenza virus in poultry in 2014-15 resulted in the destruction of more than 50 million chickens and turkeys in the U.S., causing billions of dollars in economic loss. This animal disease outbreak — the worst in U.S. history — is one example of how devastating a foreign animal disease can be to animal agriculture and the country's economy. The resurgence of avian influenza in multiple states, including Pennsylvania, is once again bringing the importance of preventing animal diseases to the forefront, noted Suresh Kuchipudi, clinical professor of microbiology in Penn State's College of Agricultural Sciences. Exploring the emergence, spread and control of animal infectious diseases such as avian influenza was the focus of the inaugural Emerging Animal Infectious Disease Conference held Nov. 29-Dec.1, 2021, at Penn State. It was hosted by the College of Agricultural Sciences, the Pennsylvania Department of A
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dented can botulism :: Article Creator Three Canadians Sickened In France's Botulism Outbreak Are From Quebec: PHAC The Public Health Agency of Canada has confirmed that the three Canadians who fell ill in a botulism outbreak in France are from Quebec. They're among at least 12 people who have suspected botulism after eating sardines prepared and served at Tchin Tchin Wine Bar in Bordeaux, France. The food was eaten between Sept. 4 and Sept. 10. The Associated Press has reported that some patients have been released from hospital, but most of them are in intensive care or critical condition. Canada's public health agency says it cannot divulge the condition of the patients from Quebec because it is considered private health information. Other tourists from the U.S., Ireland, Germany and Spain were among those sickened. One patient, who was not from Canada, has died. France's public health agency is leading the investigation
“Live Coronavirus Map Used to Spread Malware - Krebs on Security” plus 1 more
“Live Coronavirus Map Used to Spread Malware - Krebs on Security” plus 1 more Live Coronavirus Map Used to Spread Malware - Krebs on Security Posted: 12 Mar 2020 05:12 PM PDT Cybercriminals constantly latch on to news items that captivate the public's attention, but usually they do so by sensationalizing the topic or spreading misinformation about it. Recently, however, cybercrooks have started disseminating real-time, accurate information about global infection rates tied to the Coronavirus/COVID-19 pandemic in a bid to infect computers with malicious software. A recent snapshot of the Johns Hopkins Coronavirus data map, available at coronavirus.jhu.edu. In one scheme, an interactive dashboard of Coronavirus infections and deaths produced by Johns Hopkins University is being used in malicious Web sites (and possibly spam emails) to spread password-stealing malware. Late last month, a member of several Russian language cybercr
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