3hp tb treatment :: Article Creator Shorter TB Regimen Misses The Mark Shorter high-dose rifampicin regimens proved safe for treating pulmonary tuberculosis (TB), but failed to demonstrate noninferiority compared with the standard 6-month regimen, a phase III trial found. For the primary efficacy outcome, an absolute 6.3% more adults receiving a 4-month regimen that included the highest dose of rifampicin had an unfavorable outcome at 12 to 18 months versus the control group (90% CI 1.1-11.5, P=0.30 for noninferiority), reported Thomas Harrison, MD, of St. George's, University of London, and colleagues. In the control group, an unfavorable outcome -- a composite that included treatment failure, relapse, or death likely due to TB -- was observed in 7%; with the 4-month regimens, an unfavorable outcome was observed in 13.4% of patients assigned to a 1,800-mg rifampicin dose and 10% of those on a 1,200-mg rifampicin dose, according to the