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large cell neuroendocrine carcinoma lung :: Article Creator Small-Cell And Non-Small-Cell Lung Cancer: What's The Difference? Lung cancer is the leading cause of cancer deaths among both men and women. Small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) are the two main types of lung cancer. Most lung cancers are NSCLC. Only about 15% of lung cancers are SCLC. Their names stem from what their cells look like when you look at them under a microscope. SCLC cells look round and undersized in comparison to NSCLC cells. But the big difference is how aggressive they are. SCLC is more aggressive than NSCLC and often spreads to other parts of your body. Here are the facts about SCLC and NSCLC and how they differ. Small-cell lung cancer is when abnormal cells in your lung grow fast and uncontrollably. It's an aggressive form of cancer that often starts in your airways and then spreads, or metastasizes, to other parts of your ...